Obviously if you have crushing chest pain, or any kind of chest pain, or if you have acute shortness of breath, those are things we want you to go to the ER for
Most headaches result from indirect effects, such as dehydration or changes in blood sugar levels, rather than the medication directly affecting the brain
The Mounjaro (tirzepatide) UK SmPC advises using a barrier method of contraception for four weeks after initiation and after each dose escalation, as tirzepatide has been shown to reduce oral contraceptive exposure during these periods

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PMID: 28935036, PMCID: PMC8412839, DOI: 10.1016/j.jacc.2017.07.775