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Note: Retatrutide is currently an investigational peptide

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Providers may consider combination therapy when single-agent response plateaus or tolerability is favorable

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The Biopterin (BH4) Cycle The biopterin cycle consists of only two substances: Tetrahydrobiopterin (BH4) Dihydrobiopterin (BH2) BH4 also acts as a cofactor in various chemical reactions, where it becomes BH2