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GLP-1s are also not appropriate for : Individuals who are underweight or undernourished Those at risk for sarcopenia (muscle loss) People with low muscle mass or nutritional deficiencies Adults over 65 with osteopenia, osteoporosis, or a recent history of fractures In these cases, reduced appetite and unintended weight loss can accelerate muscle and bone loss, making close medical supervision essential

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For individuals participating in clinical trials of retatrutide, or in future those prescribed it following any regulatory approval, managing gastrointestinal side effects proactively can significantly improve tolerability and treatment adherence

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Reduced appetite can lead to nutritional deficiencies

even though social media is not necessarily representative, a large collection of posts may reflect additional concerns. Still, the researchers emphasize that these findings do not prove causation