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This is a natural process, similar to how a sliced apple turns brown when exposed to air

The GHRP component appeared to sensitize somatotrophs to GHRH by mobilizing intracellular calcium stores through the Gq pathway, while GHRH simultaneously elevated cAMP via Gs

Klann EM, Dissanayake U, Gurrala A, Farrer M, Shukla AW, Ramirez-Zamora A, et al

Cells were cultured in mTeSR1 medium on 100-fold-diluted Matrigel matrix and routinely passaged using Accutase [1]

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doi: 10.1101/mcs.a000455 54