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Comment: Many commenters did not believe that the use of OPPS data was appropriate for these services when paid under the PFS, as the PE costs incurred in furnishing these services may not be the same across physician office and hospital outpatient settings of care

(PubMed) de Bree A, van Mierlo LA, Draijer R

As emphasized in the previous section, perhaps the most critical improvement that would have been needed for the transition from protozoan to metazoan was advanced cell-cell communication and signaling