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[30] A 2000 study to determine increases of eumelanin expression in seven, "normal volunteers" administered [Nle 4 , D-Phe 7 ]-MSH concluded that, "the tanning induced by Melanotan in the face and forearm is associated with a significant increase in the eumelanin content of the human skin." [31] Three 2004 Phase I clinical trials sought to establish the safety of [Nle 4 , D-Phe 7 ]-MSH therapy combined with UV-B light or sunlight exposure

In this sense, this review aims to provide an overview of the AR signaling in PC, its interaction with miRNAs and curcumin, and the currently available curcumin nanoformulations that can be implemented as possible therapeutic solutions in both normal and aggressive forms of PC

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