Preclinical studies indicate that metformin promotes M2 macrophage polarization through STAT6 activation, which facilitates tissue repair and attenuates TGF-1-mediated renal fibrosis (109)
B12 supports liver health through its role in methionine synthesis and the methylation cycle that the liver depends on for detoxification
Avoid exposure to direct sunlight or heat
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Schroeder JH, Cappadocia MC, Bebko JM, Pepler DJ, Weiss JA
It appears to do this through several mechanisms including upregulation of growth factors involved in mucosal repair, reduction of inflammatory mediators, and support of gut barrier integrity