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Key points include: Tirzepatide matched dulaglutides cardiovascular outcomes in a high-risk secondary-prevention population

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12 , e008054 (2024)

These factors promote the transcription of the MMP-13 gene by activating the MAPK and NF-B signaling pathways

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Clinical trials have directly compared these medications, and the results consistently favour Mounjaro: In the SURMOUNT-5 head-to-head trial, participants on tirzepatide lost an average of 20.2% of their body weight compared to 13.7% for semaglutide over 72 weeks