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Pre-clinical studies showed that anti-atherogenic effect of GLP-1 is independent of modulation of plasma lipid levels and depends on anti-inflammatory response

A number of nutritionists have responded by cautioning that the human experiments were a lot less convincing than the ones in mice, and while provocative, didnt demonstrate that artificial sweeteners cause harm to people

Trends in Endocrinology & Metabolism

Clinical trials show that GLP-1 agonists produce modest reductions in systolic blood pressure, typically 25 mmHg

Then the pandemic hit

Activated microglia release chemokines, cytokines, and reactive oxygen species, crucially contributing to neuroinflammatory cascades while disrupting neurotransmitter balance and synaptic plasticity through pro-inflammatory phenotypic transformation