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The value of another blood test, holotranscobalamin (HoloTC), decreases with vitamin B12 deficiency

Metformin, known primarily for stimulating autophagy and apoptosis via the EGFR/AKT/AMPK/mTOR pathway in SCLC (92), may indirectly influence ferroptosis given the central role of the AMPK/mTOR hub in this crosstalk, although direct evidence is required

Haughey NJ, Holden CP, Nath A, Geiger JD

The liver must metabolize both substances simultaneously, taxing its detoxification pathways

2021;28:74863.e7

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