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In addition to the VHL-HIF-VEGF/vascular endothelial growth factor receptor (VEGFR) pathway, VHL mutations affect signaling regulation in the mTOR and epidermal growth factor receptor (EGFR) pathways, promoting tumor growth (130)

1 The FDA reiterated that compounded drugs are not FDA-approved, meaning the agency does not review their safety, effectiveness, or quality prior to marketing

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