The peer-reviewed evidence summarized below is drawn from studies of each compound separately
The samples were acquired at 25 C according to literature procedure using a Biacore X100 instrument equipped with a CM5 sensor chip (GE Healthcare Biosciences) 48
The criteria for secondary structure prediction included number of nucleotides in one bulge in stem ( 12), number of base pairs in the stem region of the predicted hairpin ( 16), cutoff of free energy (kCal/mol -15), length of hairpin (up and down stems + terminal loop 50), length of hairpin loop ( 20), number of nucleotides in one bulge in mature region ( 8), number of biased errors in one bulge in mature region ( 4), number of biased bulges in mature region ( 2), number of errors in mature region ( 7), number of base pairs in the mature region of the predicted hairpin ( 12) and percent of mature sequences in stem ( 80)
In skimming the poor-quality reseach that does exist, it seemed to me that, generally speaking, patients who received more B12 generally do better than patients who received less B12, and patients who received B12 more frequently did better than patients who received B12 less frequently
Timing your medication appropriately may help with side effects for some people
Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A
