Refrigeration at temperatures between 2C and 8C is highly recommended to prevent degradation
Ballantyne CM, Herd JA, Ferlic LL, Dunn JK, Farmer JA, Jones PH, Schein JR, Gotto AM Jr
NICE guidance does not specifically address the combination of benzodiazepines with GLP-1 receptor agonists, as there is no established interaction requiring specific clinical guidance
Obesity is a well-established risk factor for postmenopausal breast cancer, and GLP-1 therapies influence several pathways implicated in cancer development, including chronic inflammation, insulin signaling, and metabolic regulation
Several studies have shown that FM patients have lower levels of monoamine neurotransmitters, which may contribute to the development of chronic pain and depressive symptoms 20,21
Clinical studies have shown that it has several antiaging and cardio- and neuro-protective properties, and can also alleviate osteoarticular, urologic, and menopause-related discomfort.60 The extract has also been found to have a photoprotective, modulating effect on skin pigmentation.61 Several RCTs evaluating the use of French maritime pine bark extract have shown a significant reduction in signs of facial aging, such as wrinkles and solar lentigines,62,63 and increased levels of hyaluronan synthase and type I collagen.64 Another RCT (n=76) showed increased skin elasticity and hydration and decreased skin darkening in Asians working in highly polluted areas after treatment for 12 weeks.65 No relevant adverse effects were reported
