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Practically speaking, if you weigh significantly more than the trial average, you may find that: The 2.5 mg initiation dose produces minimal noticeable effect You need to reach higher doses (10-15 mg) before seeing consistent results Your optimal maintenance dose trends toward the upper end of the range Conversely, if you weigh less than the trial average, lower doses may produce significant effects, and the maximum dose may not be necessary or desirable

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Those with heart failure or kidney disease may require fluid restriction

Tirzepatide produced greater average weight loss in a direct 72-week obesity trial, while semaglutide has a cardiovascular risk-reduction indication for certain adults

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