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If neurological symptoms are present (such as paraesthesia, ataxia, cognitive changes, or visual disturbances), more intensive treatment is required

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Gastrointestinal symptoms: alteration in bowel motility, such as mild diarrhea or constipation, and loss of bladder or bowel control

Reference your payer contracts or a fee schedule analysis tool rather than using Medicare rates as a proxy

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For a broader explanation of how this gap is evaluated across peptide categories, see Peptide Research vs Human Use and Peptide Side Effects