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High tolerance makes drinking more costly in terms of calories and money, limits the euphoria, and worsens the depressant effects

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Upon activation, microglia upregulate NADPH oxidase 2 which produces superoxide and inducible nitric oxide synthase, ultimately generating nitric oxide

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There are specific steps you can take to help reduce the effects of alcohol: Eat before or while drinking: Food slows the absorption of alcohol, which can help prevent BAC from rising too quickly