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Regardless of their effectiveness, the GLP-1 issue has a unique level of unaffordability caused by the following factors

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This is notably lower than the 6.21 percent average standard deviation observed for rarely utilized orphan drugs, as reported in the CY 2024 PFS final rule (88 FR 52393)

This is associated with impaired mitochondrial function, dysregulated OXPHOS, and increased ROS