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3.1.2 Alkylating agents Alkylating agents represent a distinct category of anticancer drugs with a mechanism of action centered on the formation of an unstable alkyl group R-CH2+, which subsequently reacts with nucleophilic centers on proteins and nucleic acids

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10.1182/blood-2016-10-569186 24 GreenR.AllenL

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They are also costly and subject to variable insurance coverage, leading many med spas and compounding pharmacies to offer compounded versions of these FDA-approved medications with varying degrees of safety