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(2025, April 28)

Zhang, Y., Murugesan, P., Huang, K

Not yet applicable to clinical practice

While structurally similar, PT-141 was developed specifically to target sexual dysfunction rather than pigmentation

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[78] found that Lira inhibited proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in HepG2 cells and db/db mice through hepatocyte nuclear factor 1 (HNF1)-dependent mechanism, and may inhibit LDLR expression in db/db mice through PCSK9 independent pathway, and ultimately reduce liver cholesterol accumulation