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Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials

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Key points: it maintained its primary willingness-to-pay benchmarks (notably $100k and $150k per QALY ( [8] ) ( [9] )), and clarified special rules for ultra-rare diseases and one-shot cures

The exquisite immune specificity for beta cells suggests that such cells may already harbour molecular signatures of vulnerability, which may act not only as initiators or conduits for the early immune response but also as amplifiers of ongoing beta cell-directed immune destruction (Kracht et al