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While these increases have not been associated with increased cardiovascular events in trials to date, the FDA label for Zepbound recommends heart rate monitoring, particularly in patients with cardiac disease

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Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2

But other early research suggests that semaglutide and other GLP-1 medications could interact with the brains reward system in a way that helps modulate cravings, whether for food, nicotine, alcohol or other drugs

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doi: 10.1159/000054522 20 StraderADBuntinJD