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Metabolism: We have highlighted the minimal hepatic metabolism of sitagliptin, with essentially all of the compound remaining unmetabolized in circulation

Type 2 diabetes in Japan and East Asian countries is often characterized by non-obesity and impaired insulin secretion, contrasting with the obesity-driven insulin resistance more commonly seen in Caucasian populations [2]

Context: Weight regain is not unique to GLP-1 medications

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Reduces dark spots, age spots & hyperpigmentation

(1999) documented greatly faster wound healing rates in db/db diabetic mice an animal model of impaired wound healing following T4 treatment, suggesting relevance to research on healing deficits in body disease contexts