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Tirzepatide has a higher affinity with GLP-1R than GLP-1 does (pIC 50 : 8.90 vs 8.62), and its cAMP activation activity is significantly lower (12 decrease in pEC 50 )

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Jalal et al., 2010), stroke (Lolic et al., 1997) and Alzheimer's disease (Virmani et al., 2001) and patients with Alzheimer's disease (Spagnoli et al., 1991