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[46] This theory has been challenged due to the high level of reactivity of the two free sulfhydryls, low intracellular concentrations of DHLA as well as the rapid methylation of one or both sulfhydryls, rapid side-chain oxidation to shorter metabolites and rapid efflux from the cell

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The outcome was incident ICH after apixaban initiation

In other study, exogenous spermidine increased AsA and GSH contents, activities of APX, DHAR, GR and CAT which reduced ROS production and oxidative stress under aluminium stress (Nahar et al

These systems include enzymatic antioxidants such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, as well as non-enzymatic antioxidants like vitamins C and E, glutathione, and albumin ( When this balance is disrupted, however, oxidative stress occurs, leading to significant sperm dysfunction