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Critically, this effect is glucose-dependent, meaning insulin secretion diminishes as blood glucose normalizes, substantially reducing hypoglycemia risk compared to sulfonylureas or exogenous insulin

In this retrospective cohort study, the TriNetX platform inherently manages missing data and patient follow-up based on the practices of contributing healthcare organizations

These findings, along with indications of safety and potential benefits for PAD outcomes, suggest that GLP-1RAs could be considered a preferred therapy over other anti-diabetic medications for patients with concurrent T2DM and PAD [79]