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It has been discovered that long-term exposure to arsenic alters the kidney, resulting in interstitial nephritis, glomerular hypertrophy, and tubular cell vacuolation 18

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And so we can just navigate the middle that way

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While previous findings of increased total glutathione in subjects with asthma may reflect an adaptive response whereby synthesis and mobilization of GSH is increased to combat acute insults, these previous findings are more likely due to increased GSSG formation (206) since protein SHs are also reduced in these subjects (15, 236)