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Brain-derived neurotrophic factor (BDNF) : Intranasal administration of Selank has also been shown to upregulate BDNF expression in the hippocampal area in murine models [13]

Cytochrome P450 2E1 (CYP2E1) mRNA is not reduced by GHK-Cu (RT-qPCR: P=NS), indicating protection is downstream of NAPQI generation consistent with Nrf2-driven GSH replenishment and antioxidant enzyme upregulation rather than reduced toxic metabolite production

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this phenomenon is also known as oxidative stress