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Microglia were isolated using anti-Cd11b beads (130-049-601) (Milteny Biotec, Bergisch Gladbach, Germany) due to manufacturers exact instructions

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PS-MPs activate both protective (Nrf2-Keap1) and apoptotic (p53Bcl-2/Bax) pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Roy M, Benedict K, Deak E, Kirby MA, McNiel JT, Sickler CJ, Eckardt E, Marx RK, Heffernan RT, Meece JK, Klein BS, Archer JR, Theurer J, Davis JP, Park BJ

2021;16:e0247620

However, it is likely that the activation of ERK1/2 by AA is an indirect effect dependent on a short and regulated imbalance of the intracellular redox state that would promote the presence of Ras-GTP and the consequent activation downstream of the protein kinase pathway activated by mitogens (MAPK) (Salazar et al., 2016)