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The STEP clinical program was a comprehensive, randomized, double-blind, placebo-controlled study that lasted for 68 weeks, with 7 weeks of follow-up without treatment for safety assessments

The same mitogenic activity is the basis of long-term cancer concern, because IGF-1 signaling is one of the more well-documented growth pathways studied in tumor biology

Biochem Pharmacol 2010;80:41021 [DOI] [PMC free article] [PubMed] [Google Scholar] 20.Ramachandran A, Jaeschke H.Acetaminophen toxicity: novel insights into mechanisms and future perspectives

Sami, A