July 10, 2021 Also see our answer to the question: Do supplements help with Parkinson's disease treatment or prevention
A separate 2025 study in Bioinorganic Chemistry and Applications demonstrated that Semax reduced reactive oxygen species (ROS) production associated with amyloid-beta/copper interactions a mechanistically distinct neuroprotective pathway unrelated to BDNF activity
Honaker 2008, Hauge 2011 ): avoidance of caffeine, nicotine, red wine, and other migraine triggers stress reduction (see the Stress Management protocol) improving sleep hygiene (see the Insomnia protocol) massage therapy chiropractic manipulation acupuncture getting sufficient exercise and frequent stretching 8 Dietary Interventions A significant association between dietary intake and migraine incidence exists
Interactions with aging processes remain unknown
It is not FDA-approved and appears on the FDAs Category 2 list of bulk substances that may present significant safety risks (insufficient human safety data, potential immunogenicity, or impurities)
So a molecule that seems to talk directly to fibroblasts, and that the body stocks less of with age, is an obvious candidate for the microscope