In the majority of patients, the cause is still unknown
Instead of following the standard escalation schedule, a tirzepatide microdose protocol uses doses below the 2.5 mg starting point and increases more slowly over a longer period
Clinicians often start with basal insulin at a stable dose, then introduce or titrate tirzepatide gradually
We found several metabolites that were associated with clinical parameters in glaucoma and had high accuracy to distinguish glaucoma
In acute and complex cases, treatment is usually surgical
Briefly, whole Drosophila were fixed in 4% PFA for 12 h at 4 C, then rinsed 3 PBS for 3 h at RT with gentle shaking, and then immersed in FlyClear Solution-1 (8% THEED (2,2,2,2- (Ethylenedinitrilo)-tetraethanol) (Sigma-Aldrich), 5% Triton X-100 (Sigma-Aldrich) and 25% Urea (Fisher Scientific, in PBS) for 14 days at 37 C, as described previously 26