PMID: 19126664
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BPC 157 was given per-orally, in drinking water (10 g/kg, 10 ng/kg, i.e., 0.16 g/ml, 0.16 ng/ml, and 12 ml/rat/day) till sacrifice, or alternatively, 10 g/kg and 10 ng/kg intraperitoneally
Splitting the daily dose into morning and evening injections maintains steadier peptide availability for ongoing tissue support
The GLP-1R and GIPR pathways both converge on beta cell function through incretin signaling, and retatrutide provides a tool to study the amplified incretin response that occurs when both receptors are activated simultaneously