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Shubhrajit Mantry and Sanjeeb Kumar Kar would like to acknowledge Sarala Birla University, India for providing the facilities to draft this manuscript, and encouraging for conducting various research activities

Studies have found that IGF-1 DES can cause blood sugar levels to decrease, as well as to improve insulin sensitivity and blood lipids in type 2 diabetic patients

Common lab readouts: Hormone signaling markers, IGF-1related measurements, gene/protein expression panels, and endocrine/metabolic biomarker tracking

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However, the levels of other metabolites such as 5-Aminolevulinate, cysteate, putrescine, 4-Aminobutyraldehyde, kynurenine, serotonin, Formyl-5-hydroxykynurenamine, 5-Hydroxykynurenine, 2-Aminomuconate, xanthine, and 5-Aminolevulinate were significantly increased in LC patients ( Figure 3C , Supplementary Figure 3A )

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