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Resonance assignments have been deposited to the BMRB under the accession codes 52458 (FOXO4-LRI) and 52457 (p53TAD2 bound to FOXO4-DRI)

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Brain Microvascular Endothelial Cells (Blue) are cultured on the top of the transwell and Pericytes and Astrocytes are cultured (Orange and Green) on the bottom of the transwell to form a barrier that mimics an in vivo model

Among them, five drugs exhibited the most significant divergence, with sermorelin emerging as the top candidate due to its lowest p-value and highest difference values in both discovery and validation cohorts [1]