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However, compounded drugs are not FDA approved, which means FDA does not review them for safety, effectiveness or quality before they are marketed

Zhu J, Zhu J, Springer TA

Observation periods included the in-trial period (that is, while in the trial, regardless of treatment discontinuation or rescue intervention) and the on-treatment period (with trial product)

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Though, look, if you get your levels tested before and after brushing for a few months and they go up, you could presumably stick with it