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The results of chromatin immunoprecipitation assays demonstrated that DRD2 activation increases Gclc and Gclm expression by enhancing the binding of Nrf2 to their gene promoters (Fig

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In particular the stimulation of beta cell function and inhibition of glucagon secretion were important, since insufficient insulin secretion and hypersecretion of glucagon were at that time emerging as the key defects underlying type 2 diabetes (63, 64)

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