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Signaling-metabolism interplay: regulatory circuits reinforcing CSC stemness An important paradigm shift has occurred in recent years: signaling pathways are no longer viewed in isolation from cellular metabolism, particularly in CSCs

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The reduced reabsorption of Na + from the lumen of the tubule activates the basolateral membrane-associated Na + /Ca 2+ exchanger identified as NCX1 (encoded by the SLC8A1 gene)

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Pharmacology and potential implications of nicotinamide adenine dinucleotide precursors