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Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells

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Genome-wide analyses reveal thousands of differentially methylated sites affecting steroid hormone signaling and inflammation pathways ( Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis