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The phenotypic transformation of PDGF-BB-induced PASMCs is accompanied by abnormalities in pyruvate metabolism and glycolysis/gluconeogenesis pathways, with changes in the levels of metabolites such as pyruvate and lactic acid providing metabolic support for cell proliferation (Zhang M.-J
The effect of the endocannabinoid system including anandamide: In the CNS, CB1 receptors are expressed pre-synaptically on both glutamatergic and GABAergic interneurons, and activation of these receptors results in inhibition of synaptic transmission, including glutamate release It slows down the activity which leads to seizures
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doi:10.1111/head.13618 Tuncel D, Tolun FI, Gokce M, Imrek S, Ekerbier H
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