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Specifically, DHA significantly influences the biophysical characteristics of neuronal and glial cell membranes, facilitating immunomodulatory effects (13, 54)

Despite earlier beliefs of AAVs being free of insertional mutagenesis, some studies suggest that AAV has a propensity to integrate randomly into the genome at double strand breaks (DSBs) [147], leading to tumorigenesis and liver cell hyperplasia in animals [148]

The authors also wish to thank reviewers for their constructive comments which lead to substantial improvements in the quality of the manuscript

2 Harris RC, Wise JA, Price KA, et al