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While rare, they can on occasion cause serious injury or death

As the image below shows, fat consumption has steadily risen over the last century since we discovered how to extract oil from crops at scale, fuelled by synthetic fertilisers

doi:10.1055/s-2004-826160

However, an alternative explanation, albeit not mutually exclusive, is direct interaction of GLP-1RAs with GLP-1R in brain regions such as the brainstem (area postrema, nucleus tractus solitarii), which are not protected by the blood-brain barrier, and are typically involved in medication-induced nausea (chemosensitive area) (5456)