However, the absence of human clinical trials means the relevance and safety of these mechanisms in humans remains unestablished
4 A larger 2026 cohort study by Eshak and colleagues used US health records to compare around 48,000 people with fibromyalgia who had been prescribed GLP-1 receptor agonists with around 48,000 matched people with fibromyalgia who hadnt
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Similarly, IRE1 dysregulation has been observed in tauopathies, PrD, and HD, highlighting its role in neurotoxicity, whereas ATF6 dysfunction exacerbates protein aggregation and has been linked to FTD and tauopathies
For an individual person, weighing risks and benefits can be helpful, Azagury said
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