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Superior Weight Loss Outcomes Head-to-head comparisons arent yet available, but trial data suggests retatrutide produces greater body weight reduction than both semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro)

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2 In addition to lifestyle modifications (diet and exercise), many pharmacologic strategies have been proposed to counter iatrogenic weight gain, including appetite suppressants (eg, pro-dopaminergic agents such as phentermine, stimulants, and amantadine), pro-anorectant anticonvulsants (eg, topiramate or zonisamide), opioid receptor antagonists (eg, olanzapine/samidorphan or naltrexone) and oral hypoglycemics such as metformin

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