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However, the upper limit of 40 mg is likely too high, as studies indicate that negative side effects can occur below this threshold

10.2174/138161210791920496 109 YouX.VlatkovicI.BabicA.WillT.EpsteinI.TushevG.et al (2015)

They demonstrated that a three-week supplementation of 1000 mg NR per day increased muscle NAD + metabolome, specifically NAAD and products of NAM clearance pathways, yet NAD + levels were not altered

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