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Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)

Cruz has treated a diverse range of patient populations, from those in good health with risk factors for heart disease to critically ill patients requiring heart transplants

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Other factors that may also influence weight loss include: Medical conditions such as hypothyroidism

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Activation of AMP-activated protein kinase (AMPK) is a proposed mechanism of action, though this is not part of the FDA-approved labeling