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While GLP-1 agonists produce dramatic results for many patients, a meaningful subset achieves suboptimal weight loss or experiences diminishing efficacy over time

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased alpha-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

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Immunity 37 , 339350 (2012)