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But some people can have diarrhea or need to use the bathroom more often

The 5 mg formulation typically represents an intermediate titration dose used to evaluate patient response and minimize gastrointestinal side effects during dose escalation in clinical studies

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2.2.4 Preparation of DOXHCl solution The DOXHCl solution was an oil solution consisting of doxycycline hyclate and an appropriate organic solvent screened in section 2.2.2