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7% of midface volume per 10 kilograms lost Researchers analyzed imaging from 20 patients on GLP-1 receptor agonists, median age 54, with an average treatment duration of 321 days and average weight loss of 11.0 kg

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In one major trial, that added up to about 13% of baseline lean mass gone over 68 weeks, which is roughly equal to what youd normally lose over 20 years of aging

Protein Intake: Ensuring you eat enough protein helps maintain muscle mass as the fat drops

Activity-induced EE was calculated by subtracting resting metabolic rate from 24-h EE

Studies show that GLP-1s decrease pain/stiffness, protect cartilage, and improve mobility, possibly preventing surgery for some