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Common side effects (nausea, constipation, diarrhea) are typically manageable and improve with slow dose titration

Furthermore, PSYs such as ibogaine robustly induce glial-derived neurotrophic factor (GDNF) expression, originally explored in addiction research but increasingly considered relevant for broader neuronal regenerative applications [19,20]

One g of RNA was reverse transcribed into cDNA using the Transcriptor First Strand cDNA synthesis kit (Roche, Indianapolis, IN, USA) and subjected to quantitative PCR using the SYBR-Green Supermix (Roche, Indianapolis, IN, USA) with the ABI Stepone Plus real-time PCR detection system (Applied Biosystems, Foster City, CA, USA)

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