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In contrast, -LA improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats [129], increases antioxidant defense through Nrf2, and reduces inflammation in T2DM (decreases TNF- and Inhibit the expression of NLRP3 and downstream inflammatory factors IL-18 and IL-1) to prevent liver steatosis and relieve HFD-induced liver lipid accumulation in T2DM rats (Table 7)
This dramatically increases its surface area, allowing it to absorb (bind to the surface of) a wide range of compounds
Holford NHG, Sheiner LB: Understanding the dose-effect relationship
JAMA Intern Med 182 , 513519 (2022)
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